Kisii town, located in south-western Kenya, is the main urban and commercial centre in Gusii Highlands.

The Kisii municipality has a population of nearly 70,000, according to 2002 estimates. Kisii town is the capital of the Kisii District. The town was formerly the headquarters of the larger Kisii district before it was split to create Nyamira and Gucha districts.

However, the town continues to serve these districts and the larger South Nyanza and Transmara region in terms of commerce.

The people who traditionally live in the Kisii District are called Kisii, or Gusii.